The Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) research center invites applications for a highly motivated postdoctoral researcher to join our team.
Childhood asthma, particularly non-atopic and virus-induced subtypes, remains a major unmet medical need due to limited treatment options. Recent genetic studies have highlighted the 17q locus and the GSDMB gene as key drivers of airway inflammation through pyroptosis, especially during rhinovirus infections. This postdoctoral project will explore the molecular mechanisms linking GSDMB to virus-induced asthma using patient-derived human airway cell models. By applying advanced techniques such as air-liquid interface cultures, siRNA silencing, and CRISPR-Cas9 genome editing, the successful candidate will investigate how targeting GSDMB can reduce airway inflammation and provide proof-of-concept for future precision medicine therapies in severe childhood asthma.
The position is available from 1 January 2026, for 2 years.
About COPSAC
COPSAC is an internationally recognized clinical research unit committed to improving the understanding, prevention, and treatment of asthma and related diseases through translational and mechanistic studies. More information about COPSAC can be found at https://copsac.com.
Responsibilities
The postdoctoral researcher will be supervised by Professor Klaus Bønnelykke, Head of COPSAC, and will work in close collaboration with the laboratory of Professor Susanne Brix (Department of Biotechnology and Biomedicine, Technical University of Denmark).
Specific responsibilities include:
- Establishment and maintenance of primary human airway cell cultures.
- Work with air-liquid interface (ALI) models.
- Application of molecular techniques including CRISPR-Cas9 genome editing.
- Collaboration with internal and external partners.
- Contribution to publications and dissemination of results.
- PhD in molecular biology, cell biology, immunology, biomedical sciences, or a related field.
- Documented hands-on experience with primary airway cell models.
- Preferably experience with air-liquid interface (ALI) models, and CRISPR-Cas9.
- Strong publication record relative to career stage.
- Ability to work independently as well as collaboratively in an interdisciplinary team.
- Good communication skills in English.
- A stimulating and collaborative research environment at COPSAC.
- Strong ties to Professor Susanne Brix’s group at DTU, offering access to complementary expertise.
- State-of-the-art facilities and technical support.
- A 2-years full-time position (37 hours per week) with the possibility of extension.
The position is a full-time postdoctoral position (37 hours per week) at COPSAC. Salary and terms of employment are set in accordance with the Agreement between the Ministry of Taxation and the Danish Confederation of Professional Associations (AC).
Application procedure
The application, in English, must be submitted online by 16 November 2025 and include:
- Motivated cover letter (max 2 pages)
- Curriculum Vitae
- Diplomas (Master’s and PhD degree)
- List of publications
- Contact information for 2–3 referees
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Gentofte Kommune
-Virksomheden tilbyder:
dagarbejde
-Arbejdsgiver:
Herlev Hospital, Ledreborg Alle, 2820 Gentofte
-Ansøgning:
Ansøgningsfrist: 16-11-2025;
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5eca1f54-b6e3-4245-a372-c6bc664abdd4
