The Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) research center invites applications for a highly motivated postdoctoral researcher to join our team.
The postdoctoral researcher will join a project developing innovative siRNA-based therapies for severe, virus-induced asthma. The project focuses on the GSDMB gene, a key genetic factor driving airway inflammation via pyroptosis. Using patient-derived airway models, the postdoc will investigate whether silencing a specific GSDMB isoform can reduce inflammation, restore epithelial integrity, and improve immune regulation. This work aims to provide proof-of-concept for targeted, personalized treatments for asthma patients who are unresponsive to conventional therapies, particularly during virus-triggered exacerbations. The position offers the opportunity to work at the intersection of genetics, immunology, and translational respiratory research.
The position is available from 1 January 2026 for 1 year, with the possibility of extension to 2 years.
About COPSAC
COPSAC is an internationally recognized clinical research unit committed to improving the understanding, prevention, and treatment of asthma and related diseases through translational and mechanistic studies. More information about COPSAC can be found at https://copsac.com.
Responsibilities
The postdoctoral researcher will be supervised by Professor Klaus Bønnelykke, Head of COPSAC, and will work in close collaboration with the laboratory of Professor Susanne Brix (Department of Biotechnology and Biomedicine, Technical University of Denmark).
Specific responsibilities include:
- Establishment and maintenance of primary human airway cell cultures.
- Work with air-liquid interface (ALI) models.
- Application of molecular techniques, including RNA silencing.
- Collaboration with internal and external partners.
- Contribution to publications and dissemination of results.
- PhD in molecular biology, cell biology, immunology, biomedical sciences, or a related field.
- Documented hands-on experience with primary airway cell models.
- Preferably experience with air-liquid interface (ALI) models and RNA silencing.
- Strong publication record relative to career stage.
- Ability to work independently as well as collaboratively in an interdisciplinary team.
- Good communication skills in English.
- A stimulating and collaborative research environment at COPSAC.
- Strong ties to Professor Susanne Brix’s group at DTU, offering access to complementary expertise.
- State-of-the-art facilities and technical support.
- A 1-year full-time position (37 hours per week) with the possibility of extension to 2 years.
The position is a full-time postdoctoral position (37 hours per week) at COPSAC. Salary and terms of employment are set in accordance with the Agreement between the Ministry of Taxation and the Danish Confederation of Professional Associations (AC).
Application procedure
The application, in English, must be submitted online by 10 November 2025 and include:
- Motivated cover letter (max 2 pages)
- Curriculum Vitae
- Diplomas (Master’s and PhD degree)
- List of publications
- Contact information for 2–3 referees
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Gentofte Kommune
-Virksomheden tilbyder:
dagarbejde
-Arbejdsgiver:
Gentofte Hospital, Ledreborg Alle, 2820 Hellerup
-Ansøgning:
Ansøgningsfrist: 16-11-2025;
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/321dc62c-ec56-4505-90c2-9749e53d7bdd
